If statins alone aren’t
enough, NEXLIZET can
Help you take control
of your Lipid Lurkers
NEXLIZET and NEXLETOL are the only oral nonstatins FDA approved to lower bad cholesterol and reduce the risk* of the first or next serious heart event† in patients with statin intolerance.
*Bempedoic acid.
†Serious heart event=cardiovascular death, heart attack, stroke, heart stent or bypass surgery.
If your bad cholesterol levels are still too high, which can threaten your heart health, ask your doctor about NEXLIZET.
One of the active ingredients in NEXLIZET, bempedoic acid, is proven to lower the risk of serious heart events, like cardiovascular death, heart attack, stroke, heart stent or bypass surgery.
NEXLIZET works differently than a statin. It contains 2 medications, bempedoic acid and ezetimibe.
Eligible commercially insured patients* may save on out-of-pocket costs each time they fill their NEXLIZET prescription.
*Terms and Conditions Apply.
NEXLIZET is a combination of 2 medicines, bempedoic acid and ezetimibe. The bempedoic acid portion of NEXLIZET was studied in a large clinical trial on reducing cardiovascular death, heart attack, stroke, heart stent or bypass surgery in people with statin intolerance.
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What are NEXLIZET and NEXLETOL?
- Along with diet and exercise:
- NEXLETOL is used, with other cholesterol-lowering medicines, or alone when use with other cholesterol-lowering medicines is not possible, to reduce low-density lipoprotein (LDL) or bad cholesterol in adults with high blood cholesterol levels called hypercholesterolemia, including a type of high blood cholesterol called heterozygous familial hypercholesterolemia.
- NEXLIZET is used to reduce LDL in adults with high blood cholesterol levels called hypercholesterolemia, including a type of high cholesterol called heterozygous familial hypercholesterolemia.
- Bempedoic acid, a component of NEXLIZET and NEXLETOL is used to lower the risk of major adverse cardiovascular events, such as death from cardiovascular disease, heart attack, stroke, stent placement or bypass surgery in adults at increased risk for these events who are unable to take recommended statin treatment or are not taking a statin.
IMPORTANT SAFETY INFORMATION
Do not take NEXLIZET if you are allergic to ezetimibe or bempedoic acid, or any ingredients in NEXLIZET or NEXLETOL. If you have any of the following signs and symptoms of a serious allergic reaction, call your healthcare provider or go to the nearest emergency room:
- swelling of your face, lips, mouth, or tongue
- wheezing
- severe itching
- fast heartbeat or pounding in your chest
- trouble breathing
- skin rashes, redness, or swelling
- dizziness or fainting
Before taking NEXLIZET or NEXLETOL, tell your healthcare provider if you:
- have or had gout
- have or had tendon problems
- are pregnant or breastfeeding or may become pregnant or plan to breastfeed. NEXLIZET or NEXLETOL may pass into your breastmilk. You and your healthcare provider should decide if you will take NEXLIZET or NEXLETOL or breastfeed.
- have moderate or severe liver problems
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements especially if you take or plan to take simvastatin, pravastatin, cyclosporine, fibrates, or cholestyramine.
NEXLIZET and NEXLETOL can cause serious side effects, including:
- increased levels of uric acid in the blood, which can lead to gout. Call your doctor if you have any of the following symptoms: severe foot pain, especially in the toe joint, warm joints, swelling, tender joints or joint redness.
- tendon rupture or injury. The risk of getting tendon problems while you take NEXLIZET or NEXLETOL is increased (1.2% vs 0.9% in placebo in Trial 1; 0.5% vs 0% in placebo in Trial 2). Stop taking NEXLIZET or NEXLETOL immediately and get medical help if you experience signs of tendon rupture such as snap or pop in tendon area, bruising after an injury in a tendon area, or unable to move or put weight on the affected area.
The most common side effects observed in trials of:
- NEXLETOL includes symptoms of the common cold or flu-like symptoms, muscle spasms, back pain, stomach pain, bronchitis, pain in shoulder, legs, or arms, anemia, increased liver enzymes, kidney problems, and gallstones.
- NEXLIZET includes symptoms of the common cold or flu-like symptoms, muscle spasms, back pain, stomach pain, bronchitis, pain in shoulder, legs, or arms, anemia, increased liver enzymes, diarrhea, joint pain, swelling of sinuses, and fatigue.
These are not all the possible side effects of NEXLIZET and NEXLETOL. Ask your healthcare provider or pharmacist for more information.
Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Please see full Prescribing Information for NEXLIZET and NEXLETOL, including Patient Product Information for NEXLIZET and NEXLETOL.
What are NEXLIZET and NEXLETOL?
- Along with diet and exercise:
- NEXLETOL is used, with other cholesterol-lowering medicines, or alone when use with other cholesterol-lowering medicines is not possible, to reduce low-density lipoprotein (LDL) or bad cholesterol in adults with high blood cholesterol levels called hypercholesterolemia, including a type of high blood cholesterol called heterozygous familial hypercholesterolemia.
- NEXLIZET is used to reduce LDL in adults with high blood cholesterol levels called hypercholesterolemia, including a type of high cholesterol called heterozygous familial hypercholesterolemia.
- Bempedoic acid, a component of NEXLIZET and NEXLETOL is used to lower the risk of major adverse cardiovascular events, such as death from cardiovascular disease, heart attack, stroke, stent placement or bypass surgery in adults at increased risk for these events who are unable to take recommended statin treatment or are not taking a statin.
IMPORTANT SAFETY INFORMATION
Do not take NEXLIZET if you are allergic to ezetimibe or bempedoic acid, or any ingredients in NEXLIZET or NEXLETOL. If you have any of the following signs and symptoms of a serious allergic reaction, call your healthcare provider or go to the nearest emergency room:
- swelling of your face, lips, mouth, or tongue
- wheezing
- severe itching
- fast heartbeat or pounding in your chest
- trouble breathing
- skin rashes, redness, or swelling
- dizziness or fainting
Before taking NEXLIZET or NEXLETOL, tell your healthcare provider if you:
- have or had gout
- have or had tendon problems
- are pregnant or breastfeeding or may become pregnant or plan to breastfeed. NEXLIZET or NEXLETOL may pass into your breastmilk. You and your healthcare provider should decide if you will take NEXLIZET or NEXLETOL or breastfeed.
- have moderate or severe liver problems
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements especially if you take or plan to take simvastatin, pravastatin, cyclosporine, fibrates, or cholestyramine.
NEXLIZET and NEXLETOL can cause serious side effects, including:
- increased levels of uric acid in the blood, which can lead to gout. Call your doctor if you have any of the following symptoms: severe foot pain, especially in the toe joint, warm joints, swelling, tender joints or joint redness.
- tendon rupture or injury. The risk of getting tendon problems while you take NEXLIZET or NEXLETOL is increased (1.2% vs 0.9% in placebo in Trial 1; 0.5% vs 0% in placebo in Trial 2). Stop taking NEXLIZET or NEXLETOL immediately and get medical help if you experience signs of tendon rupture such as snap or pop in tendon area, bruising after an injury in a tendon area, or unable to move or put weight on the affected area.
The most common side effects observed in trials of:
- NEXLETOL includes symptoms of the common cold or flu-like symptoms, muscle spasms, back pain, stomach pain, bronchitis, pain in shoulder, legs, or arms, anemia, increased liver enzymes, kidney problems, and gallstones.
- NEXLIZET includes symptoms of the common cold or flu-like symptoms, muscle spasms, back pain, stomach pain, bronchitis, pain in shoulder, legs, or arms, anemia, increased liver enzymes, diarrhea, joint pain, swelling of sinuses, and fatigue.
These are not all the possible side effects of NEXLIZET and NEXLETOL. Ask your healthcare provider or pharmacist for more information.
Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Please see full Prescribing Information for NEXLIZET and NEXLETOL, including Patient Product Information for NEXLIZET and NEXLETOL.